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KMID : 0982820050040010034
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Journal of Lung Cancer
2005 Volume.4 No. 1 p.34 ~ p.37
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Radiotherapy of Brain Metastases from Lung Cancer
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Chung Eun-Ji
Lee Sun-Min
Kim Chong-Ju
Kim Yong-Tai
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Abstract
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Purpose: Brain metastasis is estimated to occur in 10∼45% of solid cancer patients, and is the most common intracranial tumor in adults. Several neurologic symptom palliations are made with steroid therapy and whole brain irradiation.
Materials and Methods: We evaluated respectively the clinical characteristics and treatment outcome for 44 patients with metastatic brain tumor from lung cancer during the period from April 2000 to December 2003.
Results: Median age of the patients was 61 years. The male：female ratio was 2.7：1. Synchronous and metachronous brain metastasis was seen in 18 (40.9%) and 26 patients (59.1%), respectively and median duration between the diagnosis of lung cancer and brain metastases was 6 months (range 1∼18 months) in metachronous cases. Pathologic types of lung cancer were as follows: small cell lung cancer in 11 patients and non-small cell lung cancer in 33 patients (squamous cell carcinoma-13, adenocarcinoma-11, large cell carcinoma- 3, others-6). The most common symptom of brain metastasis was headache, which was in 27 patients (61.4%). Seven patients (15.9%) had a single brain metastasis while 37 patients (84.1%) had multiple brain metastases. The total radiation dose to whole brain ranged from 30 to 40 Gy (median 30 Gy). In 29 patients (65.9%) neurological symptoms were resolved after whole brain irradiation. Median survival was 18 weeks for patients with steroid therapy and whole brain radiotherapy.
Conclusion: In present study, we confirmed that whole brain irradiation is an effective palliative treatment for patients with metastatic brain tumors from lung cancer.
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KEYWORD
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Brain metastases, Lung cancer, Radiotherapy
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